View printable version, this diflucan safe during pregnancy factsheet has been written for members of the public by the UK Teratology Information Service (uktis). Uktis is a not-for-profit organisation funded by Public Health England on behalf of UK Health Departments. Uktis has been providing scientific information to health care providers since 1983 on the effects that diflucan safe during pregnancy medicines, recreational drugs and chemicals may have on the developing baby during pregnancy. Fluconazole (Diflucan) is a medicine used to treat fungal infections. The standard dose for treatment of vaginal thrush is a single 150mg tablet taken orally. Is it safe to take fluconazole in pregnancy? When deciding whether or not to take fluconazole during pregnancy it is important to weigh up the benefits of its use against the known or possible risks, some of which will depend on how many weeks pregnant you are. Most pregnant women with vaginal thrush will be advised to first try a medicine called clotrimazole that is generally considered safe in pregnancy and comes in the form of a cream or a pessary that is inserted into the vagina. If this does not clear up the thrush a single tablet (usually 150mg) of fluconazole is sometimes prescribed. Most scientific studies suggest that a single 150mg dose of fluconazole during pregnancy will not harm a baby in the womb. Thrush is very common in pregnancy. If you think you have thrush it is best to consult your doctor or midwife who will advise you as to whether treatment is recommended. What if I have already taken fluconazole during pregnancy? If you have taken any medicines it is always a good idea to let your doctor know that you are pregnant so that, if appropriate, you can decide together whether you still need the medicines that you are on and to make sure that you. Can taking fluconazole in pregnancy cause birth defects in my baby? A babys body and most internal organs are formed during the first 12 weeks of pregnancy. It is mainly during this time that some medicines are known to cause birth defects. Some (but not all) studies have found that babies born to women who took standard dose fluconazole in early pregnancy might be at increased risk of having certain types diflucan safe during pregnancy of heart defect or of cleft lip and palate. Further research is required to confirm these findings. In the meantime it is advisable for pregnant women to use clotrimazole cream and/or pessaries rather than fluconazole tablets to treat vaginal thrush during pregnancy. An overview of the studies investigating diflucan safe during pregnancy fluconazole use in pregnancy and risk of birth defects in the baby is presented below. Heart defects, one large study that reanalysed data from three smaller studies found that babies born to women who took standard dose fluconazole in early pregnancy were at slightly increased risk of having a heart defect. A further study showed that two specific types of heart defect called Tetralogy of Fallot and hypoplastic left heart might be more common in babies of women taking standard doses of fluconazole in early pregnancy. A third study did not find that babies born to women who used standard dose fluconazole were at increased risk of Tetralogy of Fallot, but did show that they might be at increased risk of having another heart defect called transposition of the great arteries.

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